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Regular use of an intranasal steroid spray may be more appropriate for patients with chronic symptoms.Daily use of an antihistamine, decongestant, or both can be considered either instead of or in addition to nasal steroids.When used as a single agent, has been shown to result in a reduction of seasonal allergic rhinitis symptoms, similar in degree to that of loratadine.The older, first-generation H1 antagonists (eg, diphenhydramine, hydroxyzine) are effective in reducing most symptoms of allergic rhinitis, but they produce a number of adverse effects (eg, drowsiness, anticholinergic effects).Competes with histamine for H1 receptors on GI tract, blood vessels, and respiratory tract, reducing hypersensitivity reactions. Pseudoephedrine stimulates vasoconstriction by directly activating alpha-adrenergic receptors of the respiratory mucosa.Relieves nasal congestion and systemic effects of seasonal allergy.

Competes with histamine for H1 receptors in GI tract, blood vessels, and respiratory tract, reducing hypersensitivity reactions. Pseudoephedrine stimulates vasoconstriction by directly activating alpha-adrenergic receptors of the respiratory mucosa.Selective leukotriene receptor antagonist that inhibits the cysteinyl leukotriene (Cys LT 1) receptor.Selectively prevents action of leukotrienes released by mast cells and eosinophils.They can be used prn, but adverse effects may limit their usefulness when taken on a daily basis.Some patients tolerate the adverse effects with prolonged use, but they may experience cognitive impairment, and driving skills may be affected.Often referred to as the nonsedating antihistamines.